Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: mTOR's role in ageing: protein synthesis or autophagy?
Author: Hands, S.
Proud, C.
Wyttenbach, A.
Citation: Aging, 2009; 1(7):586-597
Publisher: Impact Journals
Issue Date: 2009
ISSN: 1945-4589
Statement of
Sarah L. Hands, Christopher G. Proud, Andreas Wyttenbach
Abstract: The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
Keywords: ageing
protein synthesis
Rights: ©2009 Hands et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.18632/aging.100070
Published version:
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

Files in This Item:
File Description SizeFormat 
hdl_87500.pdfPublished version774.02 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.