Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/87725
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Type: Journal article
Title: Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor
Author: Collins-Praino, L.
Paul, N.
Rychalsky, K.
Hinman, J.
Chrobak, J.
Senatus, P.
Salamone, J.
Citation: Frontiers in Systems Neuroscience, 2011; 5(JULY 2011):49:1-49:14
Publisher: Frontiers Research Foundation
Issue Date: 2011
ISSN: 1662-5137
1662-5137
Statement of
Responsibility: 
Lyndsey E. Collins-Praino, Nicholas E. Paul, Kristen L. Rychalsky, James R. Hinman, James J. Chrobak, Patrick B. Senatus and John D. Salamone
Abstract: Tremor is a cardinal symptom of parkinsonism, occurring early on in the disease course and affecting more than 70% of patients. Parkinsonian resting tremor occurs in a frequency range of 3-7 Hz and can be resistant to available pharmacotherapy. Despite its prevalence, and the significant decrease in quality of life associated with it, the pathophysiology of parkinsonian tremor is poorly understood. The tremulous jaw movement (TJM) model is an extensively validated rodent model of tremor. TJMs are induced by conditions that also lead to parkinsonism in humans (i.e., striatal DA depletion, DA antagonism, and cholinomimetic activity) and reversed by several antiparkinsonian drugs (i.e., DA precursors, DA agonists, anticholinergics, and adenosine A2A antagonists). TJMs occur in the same 3-7 Hz frequency range seen in parkinsonian resting tremor, a range distinct from that of dyskinesia (1-2 Hz), and postural tremor (8-14 Hz). Overall, these drug-induced TJMs share many characteristics with human parkinsonian tremor, but do not closely resemble tardive dyskinesia. The current review discusses recent advances in the validation of the TJM model, and illustrates how this model is being used to develop novel therapeutic strategies, both surgical and pharmacological, for the treatment of parkinsonian resting tremor.
Keywords: Dopamine, adenosine A2A, acetylcholine, muscarinic, basal ganglia, caudate putamen, neostriatum, subthalamic nucleus
Rights: Copyright © 2011 Collins-Praino, Paul, Rychalsky, Hinman, Chrobak, Senatus and Salamone. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
DOI: 10.3389/fnsys.2011.00049
Published version: http://dx.doi.org/10.3389/fnsys.2011.00049
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