Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87728
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Type: Journal article
Title: Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism
Author: Collins-Praino, L.
Paul, N.
Ledgard, F.
Podurgiel, S.
Kovner, R.
Baqi, Y.
Muller, C.
Senatus, P.
Salamone, J.
Citation: European Journal of Neuroscience, 2013; 38(1):2183-2191
Publisher: John Wiley & Sons
Issue Date: 2013
ISSN: 0953-816X
1460-9568
Statement of
Responsibility: 
Lyndsey E. Collins-Praino, Nicholas E. Paul, Felicia Ledgard, Samantha J. Podurgiel, Rotem Kovner, Younis Baqi, Christa E. Müller, Patrick B. Senatus, and John D. Salamone
Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus is increasingly being employed as a treatment for parkinsonian symptoms, including tremor. The present studies used tremulous jaw movements, a pharmacological model of tremor in rodents, to investigate the tremorolytic effects of subthalamic DBS in rats. Subthalamic DBS reduced the tremulous jaw movements induced by the dopamine D2 family antagonist pimozide and the D1 family antagonist ecopipam, as well as the cholinomimetics pilocarpine and galantamine. The ability of DBS to suppress tremulous jaw movements was dependent on the neuroanatomical locus being stimulated (subthalamic nucleus vs. a striatal control site), as well as the frequency and intensity of stimulation used. Importantly, administration of the adenosine A2A receptor antagonist MSX-3 reduced the frequency and intensity parameters needed to attenuate tremulous jaw movements. These results have implications for the clinical use of DBS, and future studies should determine whether adenosine A2A antagonism could be used to enhance the tremorolytic efficacy of subthalamic DBS at low frequencies and intensities in human patients.
Keywords: Acetylcholine; dopamine; muscarinic; Parkinson’s disease; tremulous jaw movements
Rights: © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
RMID: 0020137243
DOI: 10.1111/ejn.12212
Appears in Collections:Medical Sciences publications

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