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Type: Journal article
Title: Molecular analysis of putative pneumococcal virulence proteins
Author: Paton, J.
Berry, A.
Lock, R.
Citation: Microbial Drug Resistance: mechanism, epidemiology, and disease, 1997; 3(1):1-10
Publisher: Mary Ann Liebert
Issue Date: 1997
ISSN: 1076-6294
Statement of
James C. Paton, Anne M. Berry, and Robert A. Lock
Abstract: Although the polysaccharide capsule has been recognized as a sine qua non of virulence, recent attention has focused on the role of pneumococcal proteins in pathogenesis, particularly in view of their potential as vaccine antigens. The contribution of pneumolysin, two distinct neuraminidases, autolysin, hyaluronidase, and the 37 kDa pneumococcal surface adhesin A has been examined by specifically mutagenizing the respective genes in the pneumococcal chromosome and examining the impact on virulence in animal models. The vaccine potential of these proteins has also been assessed by immunization of mice with purified antigens, followed by challenge with virulent pneumococci.
Keywords: Animals
Streptococcus pneumoniae
Pneumococcal Infections
Bacterial Proteins
Adhesins, Bacterial
Antigens, Bacterial
Amino Acid Sequence
Molecular Sequence Data
Rights: Copyright status unknown
DOI: 10.1089/mdr.1997.3.1
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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