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Type: Patent
Title: Systematic evolution of ligands by exponential enrichment: tissue selex
Author: Jensen, K.B.
Chen, H.
Morris, K.N.
Stephens, A.
Gold, L.
Issue Date: 2000
Assignee: Nexstar Pharmaceuticals, Inc.
Statement of
Inventors: Jensen Kirk, Chen Hang, Morris Kevin N., Stephens Andrew, Gold Larry. Assignee: NeXstar Pharmaceuticals, Inc. Agents: Swanson & Bratschun LLC
Abstract: A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets, including cell surface macromolecules. The nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched and the high affinity nucleic acids are amplified for further partitioning. The high affinity nucleic acid ligands are useful in capturing target cells.
Description: Publication number US6114120 A Publication type Grant Application number US 08/945,909 PCT number PCT/US1996/006060 Publication date Sep 5, 2000 Filing date May 1, 1996 Priority date May 3, 1995
Patent #: US6114120
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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