Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/88072
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Type: Journal article
Title: Technical and dosimetric aspects of iodine-125 seed reimplantation in suboptimal prostate implants
Author: Marcu, L.
Lawson, J.
Citation: British Journal of Radiology, 2013; 86(1026):130058-1-130058-10
Publisher: British Institute of Radiology
Issue Date: 2013
ISSN: 0007-1285
1748-880X
Statement of
Responsibility: 
L G Marcu and J M Lawson
Abstract: Objective: Brachytherapy employing iodine-125 seeds is an established treatment for low-risk prostate cancers. Post-implant dosimetry (PID) is an important tool for identifying suboptimal implants. The aim of this work was to improve suboptimal implants by a subsequent iodine-125 seed top-up (reimplantation), based on the PID results. Methods: Of 255 patients treated between 2009 and 2012, 6 were identified as having received suboptimal implants and were scheduled for seed top-up. Needle configurations and the number of top-up seeds were determined based on post-implant CT images as well as a reimplantation treatment plan. An average of 14 seeds per patient were implanted during each top-up. Dosimetric outcome was assessed via target parameters and doses received by organs at risk. Results: All six patients had a successful top-up, with a 67% increase in the mean dose delivered to 90% of the prostate volume and a 40% increase in the volume that receives 100% of the prescribed dose. However, the final dosimetric assessment was based on the same seed activity, as the planning system does not account for the decay of the initially implanted seeds. Although physical dosimetry is not influenced by different seed activities (doses are calculated to infinity), the radiobiological implications might be slightly different from the situation when optimal implantation is achieved with one treatment only. Conclusion: Seed reimplantation in suboptimal prostate implants is feasible and leads to successful clinical outcomes. Advances in knowledge: Suboptimal prostate implants can occur for various reasons. This work shows that seed reimplantation as salvage therapy can lead to an optimal dosimetric outcome with manageable normal tissue effects.
Keywords: Humans; Prostatic Neoplasms; Neoplasm Recurrence, Local; Iodine Radioisotopes; Treatment Outcome; Brachytherapy; Radiotherapy Dosage; Feasibility Studies; Reproducibility of Results; Radiometry; Male
Rights: © 2013 The Authors
RMID: 0020131475
DOI: 10.1259/bjr.20130058
Appears in Collections:Chemistry and Physics publications

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