Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8815
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Type: Journal article
Title: Tolerance induction by transdermal glyceryl trinitrate in rats
Author: de la Lande, I.
Stafford, I.
Horowitz, J.
Citation: Behavioural Processes, 1999; 374(1):71-75
Publisher: ELSEVIER SCIENCE BV
Issue Date: 1999
ISSN: 0014-2999
1879-0712
Abstract: Mechanisms of mild glyceryl trinitrate tolerance in rats (transdermal application; 15 mg/day/2 days) were examined in isolated aortic rings contracted with phenylephrine. Tolerance to glyceryl trinitrate was comparable in both endothelium-intact and -denuded vessels; the maximum relaxation decreased to 70-80% and the EC50 increased 3-4-fold. There was minimal cross-tolerance to acetylcholine (1.7-fold increase in EC50) and none to sodium nitroprusside. The results suggest that mild tolerance to glyceryl trinitrate in rats is mediated by mechanisms which are predominantly endothelium-independent and which produce little activation of the cellular mechanism responsible for cross-tolerance.
Keywords: Aorta
Animals
Rats
Rats, Sprague-Dawley
Nitroprusside
Phenylephrine
Nitroglycerin
Acetylcholine
Vasodilator Agents
Administration, Cutaneous
Vasodilation
Dose-Response Relationship, Drug
Drug Tolerance
Male
In Vitro Techniques
DOI: 10.1016/S0014-2999(99)00319-2
Appears in Collections:Aurora harvest 4
Medicine publications

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