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Type: Journal article
Title: Adherence and motility characteristics of clinical Acinetobacter baumannii isolates
Author: Eijkelkamp, B.
Stroeher, U.
Hassan, K.
Papadimitrious, M.
Paulsen, I.
Brown, M.
Citation: FEMS Microbiology Letters, 2011; 323(1):44-51
Publisher: Blackwell Publishing
Issue Date: 2011
ISSN: 0378-1097
Statement of
Bart A. Eijkelkamp, Uwe H. Stroeher, Karl A. Hassan, Michael S. Papadimitrious, Ian T. Paulsen, and Melissa H. Brown
Abstract: Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.
Keywords: twitching; swarming; eukaryotic cell adherence; biofilm formation; type IV pili; Australian clinical strains
Rights: © 2011 Federation of European Microbiological Societies
RMID: 0030012719
DOI: 10.1111/j.1574-6968.2011.02362.x
Appears in Collections:Molecular and Biomedical Science publications

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