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Type: Journal article
Title: Lack of inhibition of glyceryl trinitrate by diphenyleneiodonium in bovine coronary artery.
Author: de la Lande, I.
Philp, T.
Stafford, I.
Horowitz, J.
Citation: European Journal of Pharmacology, 1996; 314(3):347-350
Issue Date: 1996
ISSN: 0014-2999
Abstract: Recent studies indicate that diphenyleneiodonium is a potent inhibitor of glyceryl trinitrate-induced relaxation in rat aorta precontracted with phenylephrine. We have explored the generality of this action in bovine coronary artery precontracted with the thromboxane A2 mimetic, 9,11-dideoxy-11 alpha, 9 alpha-epoxy-methano-prostaglandin F2 alpha (U46619). Diphenyleneiodonium 0.3 microM was without effect (endothelium absent) or caused mild potentiation (0.3 microM or 10 microM; endothelium present) of the relaxant response to gylceryl trinitrate. Lack of inhibition was not due to U46619, since inhibition was still prominent in rat aorta precontracted with this agent. It is concluded that diphenyleneiodonium distinguishes between cellular mechanisms mediating vasodilator responses to glyceryl trinitrate in rat aorta and bovine coronary artery.
Keywords: Aorta, Thoracic; Coronary Vessels; Animals; Cattle; Rats; Nitroglycerin; Onium Compounds; Vasodilator Agents; Enzyme Inhibitors; In Vitro Techniques; NADPH Oxidases
RMID: 0030004966
DOI: 10.1016/S0014-2999(96)00729-7
Appears in Collections:Medicine publications

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