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Type: Journal article
Title: Inhibition of apoptosis by the expression of antisense Nedd2
Author: Kumar, S.
Citation: FEBS Letters, 1995; 368(1):69-72
Publisher: Elsevier Science B.V.
Issue Date: 1995
ISSN: 0014-5793
Abstract: Nedd2 belongs to a family of mammalian cysteine proteases which share similarity with the Caenorhabditis elegans cell death protein, Ced-3. Overexpression of Nedd2 has been shown to induce apoptosis in mammalian cells but in the absence of a specific known inhibitor, it remains to be seen whether this represents cytotoxic effects of the Nedd2 protease or the specific activation of an apoptotic pathway. The present work shows that the factor-dependent cell line FDC-P1 expressing mouse antisense Nedd2 mRNA, exhibits significant inhibition of cell death upon removal of the cytokines, thus providing evidence for a direct role of Nedd2 in mediating apoptosis.
Keywords: Cell Line
Cysteine Endopeptidases
RNA, Antisense
RNA, Messenger
Cysteine Proteinase Inhibitors
Cloning, Molecular
Caspase 2
DOI: 10.1016/0014-5793(95)00602-6
Appears in Collections:Aurora harvest
Medicine publications

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