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|Title:||Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine.|
|Citation:||Gastroenterology, 1998; 115(6):1414-1425|
|Mahin Moghaddami, Adrian Cummins, and Graham Mayrhofer|
|Abstract:||<h4>Background & aims</h4>Solitary lymphoid structures that may be sites of primary extrathymic T-cell differentiation have been described recently in murine (cryptopatches) and rat (lymphocyte-filled villi) small intestine. This study tests the hypothesis that similar structures occur in human small intestine.<h4>Methods</h4>Normal small intestine was obtained during surgery. Fixed tissue was examined histologically, and frozen sections were examined by an indirect immunoperoxidase technique using a panel of mouse monoclonal antibodies.<h4>Results</h4>A new isolated lymphoid structure, with epithelium resembling follicle-associated epithelium of Peyer's patches, is described as a lymphocyte-filled villus. These structures contain major histocompatibility complex (MHC) class II-positive dendritic cells, a majority of memory T cells, a variable B-cell component, and no evidence of immature lymphocytes that express either c-kit or CD1a. Two previously described lymphoid aggregations (isolated lymphoid follicles and submucosal lymphoid aggregations) are components of a single structure. The complete structure contains a B-cell follicle, T cells with mainly memory (CD45RO-positive) phenotype, high endothelial venules, and no detectable population of immature lymphocytes.<h4>Conclusions</h4>A new solitary lymphoid structure is described in the human small intestine. Neither these structures nor isolated lymphoid follicles appear to be similar to solitary primary lymphoid structures in rodent intestine.|
|Keywords:||Intestinal Mucosa; Intestine, Small; Lymphocytes; Humans; Cell Aggregation; Adult; Aged; Female; Male|
|Rights:||Copyright © 1998 American Gastroenterological Association|
|Appears in Collections:||Medicine publications|
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