Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8834
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dc.contributor.authorSchvarcz, E.-
dc.contributor.authorPalmer, M.-
dc.contributor.authorAman, J.-
dc.contributor.authorHorowitz, M.-
dc.contributor.authorStridsberg, M.-
dc.contributor.authorBerne, C.-
dc.date.issued1997-
dc.identifier.citationGastroenterology, 1997; 113(1):60-66-
dc.identifier.issn0016-5085-
dc.identifier.issn1528-0012-
dc.identifier.urihttp://hdl.handle.net/2440/8834-
dc.description.abstract<h4>Background & aims</h4>Marked hyperglycemia slows and hypoglycemia accelerates gastric emptying. The aim of this study was to determine the effect of physiological changes in blood glucose gastric emptying.<h4>Methods</h4>In 8 healthy subjects and 9 patients with insulin-dependent diabetes mellitus (IDDM) without gastrointestinal tract symptoms or evidence of neuropathy, gastric emptying of a mixed meal was measured by scintigraphy. Using an insulin-glucose clamp, the blood glucose concentration was stabilized at 4 and 8 mmol/L on 2 separate days.<h4>Results</h4>The intragastric retention of the solid meal component at 100 minutes was 55.2% +/- 4.5% at 8 mmol/L vs. 36.7% +/- 5.5% at 4 mmol/L (P = 0.004) in normal subjects and 44.2% +/- 4.2% vs. 35.7% +/- 4.2% (P = 0.004) in patients with IDDM. The time taken for 50% emptying of the liquid meal was 57.0 +/- 10.8 minutes at 8 mmol/L vs. 32.2 +/- 12.6 minutes at 4 mmol/L (P = 0.002) in normal subjects and 41.3 +/- 3.4 minutes vs. 29.1 +/- 3.5 minutes (P = 0.002) in patients with IDDM.<h4>Conclusions</h4>Changes in blood glucose within the normal postprandial range have a significant impact on gastric emptying in both normal subjects and patients with IDDM.-
dc.language.isoen-
dc.publisherW B SAUNDERS CO-
dc.source.urihttp://dx.doi.org/10.1016/s0016-5085(97)70080-5-
dc.subjectStomach-
dc.subjectHumans-
dc.subjectDiabetes Mellitus, Type 1-
dc.subjectTechnetium Tc 99m Aggregated Albumin-
dc.subjectBlood Glucose-
dc.subjectRadionuclide Imaging-
dc.subjectGlucose Clamp Technique-
dc.subjectCase-Control Studies-
dc.subjectGastric Emptying-
dc.subjectTime Factors-
dc.subjectAdult-
dc.subjectMale-
dc.titleChanges in blood glucose within the physiological range affect gastric emptying in normal subjects and patients with insulin dependent diabetes mellitus-
dc.typeJournal article-
dc.identifier.doi10.1016/S0016-5085(97)70080-5-
pubs.publication-statusPublished-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
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