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Type: Journal article
Title: A genome-wide association meta-analysis identifies new childhood obesity loci
Author: Bradfield, J.
Taal, H.
Timpson, N.
Scherag, A.
Lecoeur, C.
Warrington, N.
Hypponen, E.
Holst, C.
Valcarcel, B.
Thiering, E.
Salem, R.
Schumacher, F.
Cousminer, D.
Sleiman, P.
Jianhua, Z.
Berkowitz, R.
Vimaleswaran, K.
Ivonne, J.
Pennell, C.
Evans, D.
et al.
Citation: Nature Genetics, 2012; 44(5):526-531
Publisher: Nature Publishing Group
Issue Date: 2012
ISSN: 1061-4036
Statement of
Jonathan P Bradfield ... Lyle J Palmer ... et al. for the Early Growth Genetics (EGG) Consortium
Abstract: Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI.
Keywords: Early Growth Genetics Consortium; Humans; Obesity; Genetic Predisposition to Disease; Genetic Markers; Body Mass Index; Case-Control Studies; Polymorphism, Single Nucleotide; Adolescent; Adult; Genome-Wide Association Study; Young Adult; Genetic Loci
Rights: © 2012 Nature America, Inc. All rights reserved.
RMID: 0020136611
DOI: 10.1038/ng.2247
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Appears in Collections:Translational Health Science publications

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