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https://hdl.handle.net/2440/88573
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dc.contributor.author | Grzeskowiak, L. | - |
dc.contributor.author | Gilbert, A. | - |
dc.contributor.author | Morrison, J. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Developmental Origins of Health and Disease, 2012; 3(4):253-261 | - |
dc.identifier.issn | 2040-1744 | - |
dc.identifier.issn | 2040-1752 | - |
dc.identifier.uri | http://hdl.handle.net/2440/88573 | - |
dc.description.abstract | The objective was to investigate the association between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and overweight in offspring at 4-5 years of age. We conducted a retrospective cohort study using linked records from the Women's and Children's Health Network in South Australia, Australia. Women were eligible to participate if they gave birth to singleton, live-born infants between September 2000 and December 2005. Women were excluded if they received a dispensing for an antidepressant other than SSRIs or an antipsychotic or an anti-epileptic or had a chronic medical condition. Of the 6560 eligible women, 71 received a dispensing for an SSRI (exposed), 204 had a reported psychiatric illness but did not receive a dispensing for any antidepressant (untreated psychiatric illness) and 6285 did not have a reported psychiatric illness and did not receive a dispensing for any antidepressant (unexposed). Childhood overweight was classified as a body mass index >85th percentile, based on age and sex. At 4-5 years of age, female offspring of exposed mothers were less likely to be overweight compared with female offspring of mothers with an untreated psychiatric illness [adjusted Prevalence Ratio (aPR) 0.23; 95% confidence interval (CI) 0.05-0.98] and female offspring of unexposed mothers (aPR 0.27; 0.07-0.99). No association with overweight was observed among male offspring of exposed mothers compared with male offspring of mothers with an untreated psychiatric illness (aPR 1.17; 0.54-2.51) and male offspring of unexposed mothers (aPR 0.93; 0.52-1.67). Further research is required to confirm these findings and examine the potential mechanisms behind the sex-specific differences. | - |
dc.description.statementofresponsibility | L. E. Grzeskowiak, A. L. Gilbert and J. L. Morrison | - |
dc.language.iso | en | - |
dc.publisher | Cambridge University Press | - |
dc.rights | © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 | - |
dc.source.uri | http://dx.doi.org/10.1017/s2040174411000808 | - |
dc.subject | children; overweight; pregnancy; psychiatric illness; selective serotonin reuptake inhibitor | - |
dc.title | Prenatal exposure to selective serotonin reuptake inhibitors and risk of childhood overweight | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1017/S2040174411000808 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grzeskowiak, L. [0000-0001-8554-4696] | - |
Appears in Collections: | Aurora harvest 7 Paediatrics publications |
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