Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8866
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYeoh, E.-
dc.contributor.authorHolloway, R.-
dc.contributor.authorRusso, A.-
dc.contributor.authorTippett, M.-
dc.contributor.authorBermingham, H.-
dc.contributor.authorChatterton, B.-
dc.contributor.authorHorowitz, M.-
dc.date.issued1996-
dc.identifier.citationGut, 1996; 38(2):166-170-
dc.identifier.issn0017-5749-
dc.identifier.issn1468-3288-
dc.identifier.urihttp://hdl.handle.net/2440/8866-
dc.description.abstractAlthough it is well recognised that oesophageal symptoms are common during therapeutic mediastinal irradiation of intrathoracic malignant diseases, the effects of mediastinal irradiation on oesophageal function are poorly defined. To clarify the pathogenesis of these sequelae a prospective study was performed to document comprehensively the effects of mediastinal irradiation on oesophageal function. Oesophageal symptoms, barium swallow, endoscopy, and combined radionuclide scintigraphy and oesophageal manometry were evaluated in eight patients with potentially curable intrathoracic malignant disease before treatment, during the last week of mediastinal irradiation, and six to eight weeks after its completion. Before irradiation, structural abnormalities were excluded by barium swallow and endoscopy. All but one patient experienced odynophagia or dysphagia, or both, during mediastinal irradiation (p < 0.001) but endoscopic abnormalities were observed in only three patients and there was no correlation between oesophageal symptoms and endoscopic changes. Irradiation, however, had no significant effect on oesophageal motility or transit. It is concluded that oesophageal symptoms which develop during mediastinal irradiation are not a result of altered oesophageal motility or transit and may reflect increased mucosal sensitivity.-
dc.language.isoen-
dc.publisherBRITISH MED JOURNAL PUBL GROUP-
dc.source.urihttp://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1383017&blobtype=pdf-
dc.subjectEsophagus-
dc.subjectHumans-
dc.subjectMediastinal Neoplasms-
dc.subjectDeglutition Disorders-
dc.subjectEsophageal Motility Disorders-
dc.subjectRadiation Injuries-
dc.subjectEsophagoscopy-
dc.subjectProspective Studies-
dc.subjectManometry-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectMiddle Aged-
dc.subjectFemale-
dc.subjectMale-
dc.titleEffects of mediastinal irradiation on oesophageal function-
dc.typeJournal article-
dc.identifier.doi10.1136/gut.38.2.166-
pubs.publication-statusPublished-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
Appears in Collections:Aurora harvest 4
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.