Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8866
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dc.contributor.authorYeoh, E.en
dc.contributor.authorHolloway, R.en
dc.contributor.authorRusso, A.en
dc.contributor.authorTippett, M.en
dc.contributor.authorBermingham, H.en
dc.contributor.authorChatterton, B.en
dc.contributor.authorHorowitz, M.en
dc.date.issued1996en
dc.identifier.citationGut, 1996; 38(2):166-170en
dc.identifier.issn0017-5749en
dc.identifier.issn1468-3288en
dc.identifier.urihttp://hdl.handle.net/2440/8866-
dc.description.abstractAlthough it is well recognised that oesophageal symptoms are common during therapeutic mediastinal irradiation of intrathoracic malignant diseases, the effects of mediastinal irradiation on oesophageal function are poorly defined. To clarify the pathogenesis of these sequelae a prospective study was performed to document comprehensively the effects of mediastinal irradiation on oesophageal function. Oesophageal symptoms, barium swallow, endoscopy, and combined radionuclide scintigraphy and oesophageal manometry were evaluated in eight patients with potentially curable intrathoracic malignant disease before treatment, during the last week of mediastinal irradiation, and six to eight weeks after its completion. Before irradiation, structural abnormalities were excluded by barium swallow and endoscopy. All but one patient experienced odynophagia or dysphagia, or both, during mediastinal irradiation (p < 0.001) but endoscopic abnormalities were observed in only three patients and there was no correlation between oesophageal symptoms and endoscopic changes. Irradiation, however, had no significant effect on oesophageal motility or transit. It is concluded that oesophageal symptoms which develop during mediastinal irradiation are not a result of altered oesophageal motility or transit and may reflect increased mucosal sensitivity.en
dc.language.isoenen
dc.publisherBRITISH MED JOURNAL PUBL GROUPen
dc.source.urihttp://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1383017&blobtype=pdfen
dc.subjectEsophagus; Humans; Mediastinal Neoplasms; Deglutition Disorders; Esophageal Motility Disorders; Radiation Injuries; Esophagoscopy; Prospective Studies; Manometry; Aged; Aged, 80 and over; Middle Aged; Female; Maleen
dc.titleEffects of mediastinal irradiation on oesophageal functionen
dc.typeJournal articleen
dc.identifier.rmid0030004935en
dc.identifier.doi10.1136/gut.38.2.166en
dc.identifier.pubid68941-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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