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Type: Journal article
Title: Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7934-35, a region frequently affected in haematological neoplasms
Author: Kumar, S.
White, D.
Takai, S.
Turczynowicz, S.
Juttner, C.
Hughes, T.
Citation: Human Genetics, 1995; 95(6):641-644
Publisher: Springer International
Issue Date: 1995
ISSN: 0340-6717
Abstract: Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.
Keywords: Blood Cells
Chromosomes, Human, Pair 7
Cysteine Endopeptidases
In Situ Hybridization, Fluorescence
Chromosome Mapping
Genes, Regulator
Caspase 2
Proto-Oncogene Mas
DOI: 10.1007/BF00209480
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