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https://hdl.handle.net/2440/8875
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Type: | Journal article |
Title: | Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7934-35, a region frequently affected in haematological neoplasms |
Author: | Kumar, S. White, D. Takai, S. Turczynowicz, S. Juttner, C. Hughes, T. |
Citation: | Human Genetics, 1995; 95(6):641-644 |
Publisher: | Springer International |
Issue Date: | 1995 |
ISSN: | 0340-6717 1432-1203 |
Abstract: | Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed. |
Keywords: | Blood Cells Chromosomes, Human, Pair 7 Humans Leukemia Lymphoma Cysteine Endopeptidases In Situ Hybridization, Fluorescence Chromosome Mapping Apoptosis Genes, Regulator Caspase 2 Proto-Oncogene Mas |
DOI: | 10.1007/BF00209480 |
Published version: | http://dx.doi.org/10.1007/bf00209480 |
Appears in Collections: | Aurora harvest Medicine publications |
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