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|Title:||PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in supression of hematopoiesis|
|Citation:||Immunity, 1999; 11(3):369-378|
|Jean-Pierre Lévesque, Andrew C.W Zannettino, Melanie Pudney, Silvana Niutta, David N Haylock, Karen R Snapp, Geoffrey S Kansas, Michael C Berndt, Paul J Simmons|
|Abstract:||Cellular interactions are critical for the regulation of hematopoiesis. The sialomucin PSGL-1/CD162 mediates the attachment of mature leukocytes to P-selectin. We now show that PSGL-1 also functions as the sole receptor for P-selectin on primitive human CD34+ hematopoietic progenitor cells (HPC). More importantly, ligation of PSGL-1 by immobilized or soluble ligand or anti-PSGL-1 antibody results in a profound suppression of HPC proliferation stimulated by potent combinations of early acting hematopoietic growth factors. These data demonstrate an unanticipated but extremely marked growth-inhibitory effect of P-selectin on hematopoiesis and provide direct evidence that PSGL-1, in addition to its well-documented role as an adhesion molecule on mature leukocytes, is a potent negative regulator of human hematopoietic progenitors.|
|Keywords:||Bone Marrow Cells; Hematopoietic Stem Cells; Cells, Cultured; CHO Cells; Animals; Humans; NAD+ Nucleosidase; ADP-ribosyl Cyclase; Granulocyte Colony-Stimulating Factor; Interleukin-3; Membrane Glycoproteins; P-Selectin; Antigens, Differentiation; Antigens, CD; Antigens, CD34; Stem Cell Factor; Interleukin-6; Ligands; Cell Adhesion; Cell Division; Apoptosis; Hematopoiesis; Solubility; Cricetinae; Antigens, CD38|
|Appears in Collections:||Medicine publications|
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