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Type: Journal article
Title: Imaging mass spectrometry for the assessment of drugs and metabolites in tissue
Author: Trim, P.
Francese, S.
Clench, M.
Citation: Bioanalysis, 2009; 1(2):309-319
Publisher: Future Science
Issue Date: 2009
ISSN: 1757-6199
Statement of
Paul J Trim, Simona Francese, Malcolm R Clench
Abstract: The study of drug distribution within biological tissue is a key part of the development of new pharmaceuticals. Matrix-assisted laser desorption ionization-mass spectrometric imaging is a powerful new imaging technique that can be used to study the distribution of a diverse range of endogenous and xenobiotic compounds within biological tissue. Here, fundamental aspects of the technique, appropriate instrumentation and applications in the study of xenobiotics and metabolite distribution are described. Sample preparation issues and some of the challenges in data interpretation/handling are also discussed.
Keywords: Humans; Microscopy; Tissue Distribution; Mass Spectrometry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Analytic Sample Preparation Methods; Pharmaceutical Preparations
Rights: Copyright status unknown
RMID: 0030014485
DOI: 10.4155/BIO.09.33
Appears in Collections:Paediatrics publications

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