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Type: Journal article
Title: The c-Myb oncoprotein
Author: Gonda, T.
Citation: International Journal of Biochemistry and Cell Biology, 1998; 30(5):547-551
Publisher: Elsevier Science
Issue Date: 1998
ISSN: 1357-2725
Statement of
Thomas J Gonda
Abstract: The c-myb gene is the cellular homologue of the v-myb oncogenes carried by the avian leukaemia viruses AMV and E26. It encodes a transcription factor (c-Myb), as does each of the viral oncogenes, which recognises the core DNA sequence C/T-A-A-C-G/T-G via a repeated helix-turn-helix-like motif. c-myb is expressed in immature haemopoietic cells, as well as immature cells of the gastro-intestinal epithelium and is down-regulated with differentiation. Enforced expression of activated or even normal forms of Myb can transform haemopoietic cells, most often of the myeloid lineage, in vitro and in vivo. Although many genes have been identified which are likely to be regulated by c-Myb, the critical target genes involved in Myb's transforming activity are not known. Together with data showing increased c-myb expression in colonic tumours, these observations raise the possibility that c-myb may play a role in human malignant disease.
Keywords: Transcription factor; Haemopoiesis; Transformation
Rights: © 1998 Elsevier Science Ltd. All rights reserved.
RMID: 0030004919
DOI: 10.1016/S1357-2725(98)00003-X
Appears in Collections:Medicine publications

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