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Type: Journal article
Title: The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue
Author: Brisch, R.
Saniotis, A.
Wolf, R.
Bielau, H.
Bernstein, H.
Steiner, J.
Bogerts, B.
Braun, K.
Braun, A.
Jankowski, Z.
Kumaratilake, J.
Kumaritlake, J.
Henneberg, M.
Gos, T.
Citation: Frontiers in Psychiatry, 2014; 5(APR):47-1-47-11
Publisher: Frontiers
Issue Date: 2014
ISSN: 1664-0640
Statement of
Ralf Brisch, Arthur Saniotis, Rainer Wolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Katharina Braun, Zbigniew Jankowski, Jaliya Kumaratilake, Maciej Henneberg, and Tomasz Gos
Abstract: Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia. This review provides an in-depth analysis of dopamine in animal models of schizophrenia and also focuses on dopamine and cognition. Furthermore, this review provides not only an overview of dopamine receptors and the antipsychotic effects of treatments targeting them but also an outline of dopamine and its interaction with other neurochemical models of schizophrenia. The roles of dopamine in the evolution of the human brain and human mental abilities, which are affected in schizophrenia patients, are also discussed.
Keywords: animal models of schizophrenia; cannabis; cognition; dopamine; dopamine receptors; evolution of the human brain; glutamate; schizophrenia
Rights: Copyright ©2014 Brisch, Saniotis, Wolf, Bielau, Bernstein, Steiner, Bogerts, Braun, Jankowski, Kumaratilake, Henneberg and Gos. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030011428
DOI: 10.3389/fpsyt.2014.00047
Appears in Collections:Medical Sciences publications

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