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|Title:||Total synthesis of the antifungal depsipeptide petriellin A|
|Citation:||Journal of Organic Chemistry, 2011; 76(16):6686-6693|
|Publisher:||American Chemical Society|
|Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes|
|Abstract:||We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.|
|Keywords:||Amides; Peptides, Cyclic; Depsipeptides; Antifungal Agents; Molecular Structure; Cyclization|
|Description:||Publication Date (Web): July 8, 2011|
|Rights:||© 2011 American Chemical Society|
|Appears in Collections:||Chemistry publications|
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