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Type: Journal article
Title: Total synthesis of the antifungal depsipeptide petriellin A
Author: Sleebs, M.
Scanlon, D.
Karas, J.
Maharani, R.
Hughes, A.
Citation: Journal of Organic Chemistry, 2011; 76(16):6686-6693
Publisher: American Chemical Society
Issue Date: 2011
ISSN: 0022-3263
Statement of
Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes
Abstract: We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.
Keywords: Amides
Peptides, Cyclic
Antifungal Agents
Molecular Structure
Description: Publication Date (Web): July 8, 2011
Rights: © 2011 American Chemical Society
DOI: 10.1021/jo201017w
Appears in Collections:Aurora harvest 7
Chemistry publications

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