Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/89648
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Type: Journal article
Title: Total synthesis of the antifungal depsipeptide petriellin A
Author: Sleebs, M.
Scanlon, D.
Karas, J.
Maharani, R.
Hughes, A.
Citation: Journal of Organic Chemistry, 2011; 76(16):6686-6693
Publisher: American Chemical Society
Issue Date: 2011
ISSN: 0022-3263
1520-6904
Statement of
Responsibility: 
Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes
Abstract: We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.
Keywords: Amides; Peptides, Cyclic; Depsipeptides; Antifungal Agents; Molecular Structure; Cyclization
Description: Publication Date (Web): July 8, 2011
Rights: © 2011 American Chemical Society
RMID: 0020130614
DOI: 10.1021/jo201017w
Appears in Collections:Chemistry publications

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