Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/89669
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Type: Journal article
Title: Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?
Author: Wu, T.
Trahair, L.
Bound, M.
Deacon, C.
Horowitz, M.
Rayner, C.
Jones, K.
Citation: Diabetic Medicine, 2015; 32(5):595-600
Publisher: Wiley
Issue Date: 2015
ISSN: 0742-3071
1464-5491
Statement of
Responsibility: 
T. Wu, L. G. Trahair, M. J. Bound, C. F. Deacon, M. Horowitz, C. K. Rayner, and K. L. Jones
Abstract: AIMS: To evaluate the effects of the dipeptidyl peptidase-4 inhibitor sitagliptin on blood pressure and heart rate, measured during a previously reported study, in which the effects of sitagliptin during intraduodenal glucose infusion at the rate of 2 kcal/min on glucose homeostasis were examined in patients with Type 2 diabetes. METHODS: A total of 10 people with Type 2 diabetes were studied on two different days, 30 min after oral ingestion of sitagliptin (100 mg) or placebo. Intraduodenal glucose was infused at 2 kcal/min (60 g over 120 min), and blood pressure, heart rate, plasma glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (total and intact), glucose, insulin and glucagon responses were evaluated. RESULTS: In response to intraduodenal glucose infusion, heart rate (treatment effect: P = 0.001) and serum insulin concentration (treatment × time interaction: P = 0.041) were higher after sitagliptin treatment than placebo, without a significant difference in blood pressure, plasma glucagon or glucose. During intraduodenal glucose infusion, there was a substantial increase in plasma total glucose-dependent insulinotropic polypeptide on both days (time effect: P < 0.001), but not in total glucagon-like peptide-1. After sitagliptin, plasma intact glucagon-like peptide-1 concentration increased slightly (treatment × time interaction: P = 0.044) and glucose-dependent insulinotropic polypeptide concentration increased substantially (treatment × time interaction: P = 0.003).The heart rate response to intraduodenal glucose was related directly to plasma intact glucose-dependent insulinotropic polypeptide concentrations (r = 0.75, P = 0.008). CONCLUSIONS: Sitagliptin increased the heart rate response to intraduodenal glucose infusion at 2 kcal/min in people with Type 2 diabetes, which was associated with augmentation of plasma intact glucose-dependent insulinotropic polypeptide concentrations. These observations warrant further clarification of a potential role for glucose-dependent insulinotropic polypeptide in the control of the 'gut-heart' axis.
Keywords: Duodenum; Humans; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucose; Hypoglycemic Agents; Administration, Oral; Retrospective Studies; Double-Blind Method; Homeostasis; Blood Pressure; Heart Rate; Time Factors; Aged; Male; Dipeptidyl-Peptidase IV Inhibitors; Sitagliptin Phosphate
Description: Short report: treatment
Rights: © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK
RMID: 0030015605
DOI: 10.1111/dme.12622
Appears in Collections:Medicine publications

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