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https://hdl.handle.net/2440/8995
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Type: | Journal article |
Title: | Exacerbation of postural tremor with emergence of Parkinsonism following neuroleptic administration |
Author: | Playford, E. Britton, T. Thompson, P. Brooks, D. Findley, L. Marsden, C. |
Citation: | Journal of Neurology, Neurosurgery and Psychiatry, 1995; 58(4):487-489 |
Publisher: | BMJ Publishing Group |
Issue Date: | 1995 |
ISSN: | 0022-3050 1468-330X |
Abstract: | Neuroleptic medication in three patients with prior isolated postural arm tremor led to a conspicuous deterioration; the postural tremor increased in amplitude, tremor appeared at rest, and other signs of mild parkinsonism developed. Withdrawal of neuroleptic drugs led to improvement in tremor and disappearance of parkinsonism. Positron emission tomography showed no reduction in uptake of [18F]dopa into nigrostriatal terminals suggesting that these patients did not have Parkinson's disease. Neuroleptic drugs can convert postural essential arm tremor into that characteristic of Parkinson's disease in patients with no evident nigrostriatal lesion. |
Keywords: | Humans Parkinson Disease, Secondary Tremor Antipsychotic Agents Posture Adult Aged Female Male |
DOI: | 10.1136/jnnp.58.4.487 |
Published version: | http://dx.doi.org/10.1136/jnnp.58.4.487 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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