Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8996
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Modulation of primary orthostatic tremor by magnetic stimulation of the motor cortex
Author: Tsai, C.
Semmler, J.
Kimber, T.
Thickbroom, G.
Stell, R.
Mastaglia, F.
Thompson, P.
Citation: Journal of Neurology, Neurosurgery and Psychiatry, 1998; 64(1):33-36
Publisher: BMJ PUBLISHING GROUP
Issue Date: 1998
ISSN: 0022-3050
1468-330X
Abstract: OBJECTIVES:To study the role of corticomotor neuronal pathways in primary orthostatic tremor. METHODS:Transcranial magnetic stimuli at an intensity 10% above the resting motor threshold were delivered over the leg motor cortex in two patients with primary orthostatic tremor while standing still. Electromyographic responses in both tibialis anterior muscles were recorded after 20 stimuli given randomly at intervals of 120 to 180 seconds. Differences between predicted and actual times of occurrence of tremor bursts after the stimuli were used to calculate a resetting index, with a value of 0 representing no resetting and a value of 1 representing complete resetting. RESULTS:Transcranial magnetic stimulation evoked EMG responses in both tibialis anterior muscles, followed by transient suppression of tremor before reappearance of rhythmic EMG activity. Analysis of the timing of tremor bursts from EMG recordings before and after the magnetic stimuli disclosed that the phase of orthostatic tremor could be reset by brain stimulation (mean resetting indices 0.93 and 0.82). CONCLUSION:The results suggest that a central oscillator, involving the motor cortex, has a crucial role in either the generation or modulation of orthostatic tremor.
Keywords: Muscle, Skeletal; Motor Cortex; Neural Pathways; Humans; Tremor; Electromyography; Linear Models; Predictive Value of Tests; Physical Stimulation; Reaction Time; Posture; Magnetics; Time Factors; Middle Aged; Female
RMID: 0030004854
DOI: 10.1136/jnnp.64.1.33
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.