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https://hdl.handle.net/2440/89974
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dc.contributor.author | Kupelian, V. | - |
dc.contributor.author | Araujo, A. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | McKinlay, J. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The Journal of Urology, 2015; 193(2):581-586 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.issn | 1527-3792 | - |
dc.identifier.uri | http://hdl.handle.net/2440/89974 | - |
dc.description.abstract | PURPOSE: Increasing evidence suggests a possible link between lower urinary tract symptoms and chronic illnesses. We determined whether lower urinary tract symptoms are associated with incident type 2 diabetes and heart disease in a population based study. MATERIALS AND METHODS: BACH is a population based epidemiological survey of urological symptoms. A multistage, stratified, cluster sample design was used to obtain a random sample of 4,144 men and women 30 to 79 years old at baseline. Median followup was 4.8 years between baseline (2002 to 2005) and followup (2006 to 2010). Type 2 diabetes and heart disease were assessed by self-report. Lower urinary tract symptoms were assessed by the AUA-SI, and voiding and storage subscores. Logistic regression was used to estimate the OR and 95% CI, and adjust for potential confounders. RESULTS: In participants with a body mass index of 30 kg/m(2) or greater the adjusted ORs for incident heart disease were 1.89 (95% CI 1.05, 3.39) for AUA-SI 8 or greater and 2.32 (95% CI 1.33, 4.05) for a storage score of 4 or greater. In participants with abdominal obesity the adjusted ORs for incident type 2 diabetes were 2.06 (95% CI 1.19, 3.55) for AUA-SI 8 or greater and 1.81 (95% CI 1.04, 3.15) for a storage score of 4 or greater. Lower urinary tract symptoms (AUA-SI 8 or greater) were also predictive of type 2 diabetes in men and women younger than 50 years (adjusted OR 2.37, 95% CI 1.18, 4.80). CONCLUSIONS: Longitudinal results of BACH suggest that lower urinary tract symptoms are a marker of increased risk for type 2 diabetes and heart disease in obese men and women. The increased risk in younger men and women suggests that lower urinary tract symptoms may be an indicator of impending disease. | - |
dc.description.statementofresponsibility | Varant Kupelian, Andre B. Araujo, Gary A. Wittert, John B. McKinlay | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.juro.2014.08.097 | - |
dc.subject | diabetes mellitus | - |
dc.subject | heart diseases | - |
dc.subject | lower urinary tract symptoms | - |
dc.subject | risk | - |
dc.subject | type 2 | - |
dc.subject | urinary tract | - |
dc.title | Association of moderate to severe lower urinary tract symptoms with incident type 2 diabetes and heart disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.juro.2014.08.097 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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