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Type: Journal article
Title: Segmental colonic transit after oral ⁶⁷Ga-citrate in healthy subjects and those with chronic idiopathic constipation
Other Titles: Segmental colonic transit after oral (67)Ga-citrate in healthy subjects and those with chronic idiopathic constipation
Author: Bartholomeusz, D.
Chatterton, B.
Bellen, J.
Gaffney, R.
Hunter, A.
Citation: Journal of Nuclear Medicine, 1999; 40(2):277-282
Publisher: Society of Nuclear Medicine and Molecular Imaging
Issue Date: 1999
ISSN: 0161-5505
Statement of
Dylan Bartholomeusz, Barry E. Chatterton, Johan C. Bellen, Robert Gaffney and Andrew Hunter
Abstract: <h4>Unlabelled</h4>Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation.<h4>Methods</h4>Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time.<h4>Results</h4>There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients.<h4>Conclusion</h4>Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit.
Keywords: Colon
Chronic Disease
Gallium Radioisotopes
Indium Radioisotopes
Pentetic Acid
Radionuclide Imaging
Gastrointestinal Transit
Administration, Oral
Aged, 80 and over
Middle Aged
Rights: © Copyright 1999 SNMMI; all rights reserved.
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