Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/90006
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Type: Journal article
Title: Manganese uptake and streptococcal virulence
Author: Eijkelkamp, B.
McDevitt, C.
Kitten, T.
Citation: Biometals, 2015; 28(3):491-508
Publisher: Springer Verlag
Issue Date: 2015
ISSN: 1572-8773
0966-0844
Statement of
Responsibility: 
Bart A. Eijkelkamp, Christopher A. McDevitt, Todd Kitten
Abstract: Streptococcal solute-binding proteins (SBPs) associated with ATP-binding cassette transporters gained widespread attention first as ostensible adhesins, next as virulence determinants, and finally as metal ion transporters. In this mini-review, we will examine our current understanding of the cellular roles of these proteins, their contribution to metal ion homeostasis, and their crucial involvement in mediating streptococcal virulence. There are now more than 35 studies that have collected structural, biochemical and/or physiological data on the functions of SBPs across a broad range of bacteria. This offers a wealth of data to clarify the formerly puzzling and contentious findings regarding the metal specificity amongst this group of essential bacterial transporters. In particular we will focus on recent findings related to biological roles for manganese in streptococci. These advances will inform efforts aimed at exploiting the importance of manganese and manganese acquisition for the design of new approaches to combat serious streptococcal diseases.
Keywords: Animals; Humans; Streptococcus; Manganese; Bacterial Proteins; Virulence
Description: Published online 05 February 2015
Rights: © Springer Science+Business Media New York 2015
RMID: 0030021589
DOI: 10.1007/s10534-015-9826-z
Grant ID: http://purl.org/au-research/grants/arc/DP120103957
http://purl.org/au-research/grants/nhmrc/1022240
http://purl.org/au-research/grants/nhmrc/1080784
Appears in Collections:Molecular and Biomedical Science publications

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