Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9001
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dc.contributor.authorJones, K.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorWishart, J.en
dc.contributor.authorMaddox, A.en
dc.contributor.authorHarding, P.en
dc.contributor.authorChatterton, B.en
dc.date.issued1995en
dc.identifier.citationJournal of Nuclear Medicine, 1995; 36(12):2220-2228en
dc.identifier.issn0161-5505en
dc.identifier.issn1535-5667en
dc.identifier.urihttp://hdl.handle.net/2440/9001-
dc.description.abstractThe aim of this study was to evaluate the prevalence of disordered intragastric meal distribution and the relationships between gastric emptying, intragastric distribution, glycemic control and gastrointestinal symptoms in diabetes mellitus. METHODS: Eighty-six patients with diabetes mellitus had measurements of gastric emptying and intragastric distribution of a radioisotopically labeled solid/liquid meal (100 g beef and 150 ml 10% dextrose), glycemic control (plasma glucose concentrations), upper gastrointestinal symptoms (questionnaire) and autonomic nerve function (cardiovascular reflexes). Results were compared to those obtained in 20 normal volunteers. RESULTS: Solid and liquid gastric emptying were delayed in the diabetic patients and correlated weakly. Intragastric meal distribution was also often abnormal, with increased retention of both solid and liquid in the proximal stomach and increased retention of solid but not liquid in the distal stomach. In all patients with increased retention of solid in the proximal stomach, emptying from the total stomach was delayed. Gastric emptying of liquid was slower in those subjects who had a mean plasma glucose > 15 mmol/liter during the gastric emptying measurement, when compared to the remainder of the group. CONCLUSION: In patients with diabetes mellitus, there is poor relationship between solid and liquid gastric emptying and intragastric meal distribution is frequently abnormal. Interpretation of the results of gastric emptying measurements should consider meal composition and plasma glucose concentrations.en
dc.description.statementofresponsibilityKaren L. Jones, Michael Horowitz, Judith M. Wishart, Anne F. Maddox, Philip E. Harding and Barry E. Chattentonen
dc.language.isoenen
dc.publisherSociety of Nuclear Medicineen
dc.subjectStomach; Humans; Gastroparesis; Diabetic Retinopathy; Diabetic Nephropathies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Indium Radioisotopes; Technetium Tc 99m Sulfur Colloid; Pentetic Acid; Blood Glucose; Prevalence; Case-Control Studies; Gastric Emptying; Food; Middle Aged; Female; Maleen
dc.titleRelationships between gastric emptying, intragastric meal distribution and blood glucose concentrations in diabetes mellitusen
dc.typeJournal articleen
dc.identifier.rmid0030004850en
dc.identifier.pubid68856-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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