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Type: Journal article
Title: Control of gene expression in the temperate coliphage 186. X. The cl repressor directly represses transcription of the late control gene B
Author: Dibbens, J.A.
Gregory, S.L.
Egan, J.B.
Citation: Molecular Microbiology, 1992; 6(18):2643-2650
Publisher: Wiley
Issue Date: 1992
ISSN: 0950-382X
Statement of
Justin A. Dibbens, Stephen L. Gregory and J. Barry Egan
Abstract: We have found that the repressor of 186 lytic transcription, CI, represses transcription of the late control gene B, with no involvement of the B protein Itself. In clone studies we showed that CI repressed transcription from the B promoter and that temperature inactivation of CIts led to B derepression. We conclude that CI repressor directly represses transcription of the Bgene and, with prophage induction, it is probable that the inactivation of the CI repressor not only derepresses early lytic transcription, but also derepresses B gene transcription, leading to the activation of transcription from the late promoters.
Keywords: Coliphages; Transcription Factors; Repressor Proteins; Viral Proteins; Virus Activation; Transcription, Genetic; Gene Expression Regulation, Viral; Amino Acid Sequence; Base Sequence; Genes, Viral; Molecular Sequence Data
RMID: 0030013037
DOI: 10.1111/j.1365-2958.1992.tb01441.x
Appears in Collections:Genetics publications

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