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Type: Journal article
Title: The role of oral flora in the development of chemotherapy-induced oral mucositis
Author: Stringer, A.
Logan, R.
Citation: Journal Of Oral Pathology and Medicine, 2015; 44(2):81-87
Publisher: John Wiley & Sons
Issue Date: 2015
ISSN: 0904-2512
Statement of
Andrea M. Stringer and Richard M. Logan
Abstract: Chemotherapy-induced mucositis is considered to be a major oncological problem, caused by the cytotoxic effects of cancer chemotherapy. In the last 10 years, there have been significant advances in the understanding of mucositis pathobiology. At the basic level, it is now well-understood that it is not just an epithelial process, but rather a complex interaction between epithelial and connective tissue compartments. There is also potential interaction between the oral microenvironment and the development of mucositis. Changes occur in the resident oral flora (commensal) throughout cancer treatment, and it is conceivable that these organisms and changes that occur may have an influence on the development of mucosal toxicity associated with cancer treatment. The aim of this review was to examine the potential contributions of oral microflora in the pathobiology of mucositis and identify pathways and interactions that could be targeted for therapeutic management of mucositis.
Keywords: microbiota
nuclear factor kappa B
oral cavity
reactive oxygen species
Rights: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DOI: 10.1111/jop.12152
Appears in Collections:Aurora harvest 7
Medical Sciences publications

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