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Type: Journal article
Title: Pregnancy, obesity and insulin resistance: maternal overnutrition and the target windows of fetal development
Author: Muhlhausler, B.
Gugusheff, J.
Ong, Z.
Vithayathil, M.
Citation: Hormone Molecular Biology and Clinical Investigation, 2013; 15(1):25-36
Publisher: De Gruyter
Issue Date: 2013
ISSN: 1868-1883
Statement of
Beverly S. Muhlhausler, Jessica R. Gugusheff, Zhi Yi Ong and Mini A. Vithayathil
Abstract: A substantial body of literature has demonstrated that the nutritional environment an individual experiences before birth or in early infancy is a key determinant of their health outcomes across the life course. This concept, the developmental origins of health and disease (DOHaD) hypothesis, was initially focused on the adverse consequences of exposure to a suboptimal nutrient supply and provided evidence that maternal undernutrition, fetal growth restriction, and low birth weight were associated with heightened risk of central adiposity, insulin resistance, and cardiovascular disease. More recently, the epidemic rise in the incidence of maternal obesity has seen the attention of the DOHaD field turn toward identifying the impact on the offspring of exposure to an excess nutrient supply in early life. The association between maternal obesity and increased risk of obesity in the offspring has been documented in human populations worldwide, and animal models have provided critical insights into the biological mechanisms that drive this relationship. This review will discuss the important roles that programming of the adipocyte and programming of the central neural networks which control appetite and reward play in the early life programming of metabolic disease by maternal overnutrition. It will also highlight the important research gaps and challenges that remain to be addressed and provide a personal perspective on where the field should be heading in the coming 5-10 years.
Keywords: adipose tissue; appetite; fatty acids; fetal programming; maternal nutrition
Rights: Copyright of Hormone Molecular Biology & Clinical Investigation is the property of De Gruyter
RMID: 0030016513
DOI: 10.1515/hmbci-2013-0029
Appears in Collections:Agriculture, Food and Wine publications

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