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dc.contributor.authorManley, B.-
dc.contributor.authorOwen, L.-
dc.contributor.authorDoyle, L.-
dc.contributor.authorAndersen, C.-
dc.contributor.authorCartwright, D.-
dc.contributor.authorPritchard, M.-
dc.contributor.authorDonath, S.-
dc.contributor.authorDavis, P.-
dc.identifier.citationNew England Journal of Medicine, 2013; 369(15):1425-1433-
dc.description.abstractBACKGROUND: The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation. However, data on the efficacy or safety of such cannulae in this population are lacking. METHODS: In this multicenter, randomized, noninferiority trial, we assigned 303 very preterm infants to receive treatment with either high-flow nasal cannulae (5 to 6 liters per minute) or nasal CPAP (7 cm of water) after extubation. The primary outcome was treatment failure within 7 days. Noninferiority was determined by calculating the absolute difference in the risk of the primary outcome; the margin of noninferiority was 20 percentage points. Infants in whom treatment with high-flow nasal cannulae failed could be treated with nasal CPAP; infants in whom nasal CPAP failed were reintubated. RESULTS: The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with treatment failure occurring in 52 of 152 infants (34.2%) in the nasal-cannulae group and in 39 of 151 infants (25.8%) in the CPAP group (risk difference, 8.4 percentage points; 95% confidence interval, -1.9 to 18.7). Almost half the infants in whom treatment with high-flow nasal cannulae failed were successfully treated with CPAP without reintubation. The incidence of nasal trauma was significantly lower in the nasal-cannulae group than in the CPAP group (P=0.01), but there were no significant differences in rates of serious adverse events or other complications. CONCLUSIONS: Although the result for the primary outcome was close to the margin of noninferiority, the efficacy of high-flow nasal cannulae was similar to that of CPAP as respiratory support for very preterm infants after extubation. (Funded by the National Health and Medical Research Council; Australian New Zealand Clinical Trials Network number, ACTRN12610000166077.).-
dc.description.statementofresponsibilityBrett J. Manley, Louise S. Owen, Lex W. Doyle, Chad C. Andersen, David W. Cartwright, Margo A. Pritchard, Susan M. Donath, and Peter G. Davis-
dc.publisherMassachusetts Medical Society-
dc.rightsCopyright © 2013 Massachusetts Medical Society. All rights reserved.-
dc.subjectTreatment Failure-
dc.subjectOxygen Inhalation Therapy-
dc.subjectContinuous Positive Airway Pressure-
dc.subjectGestational Age-
dc.subjectInfant, Newborn-
dc.subjectInfant, Premature-
dc.subjectAirway Extubation-
dc.titleHigh-flow nasal cannulae in very preterm infants after extubation-
dc.typeJournal article-
dc.identifier.orcidAndersen, C. [0000-0002-1364-4986]-
Appears in Collections:Aurora harvest 2
Paediatrics publications

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