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Type: Journal article
Title: Serum microRNAs as potential biomarkers of mandibular prognathism
Author: Gu, Y.
Zhang, Y.
Zhao, C.
Pan, Y.
Smales, R.
Wang, H.
Ni, Y.
Zhang, H.
Ni, J.
Ma, J.
Wang, L.
Citation: Oral Diseases, 2014; 20(1):55-61
Publisher: Wiley
Issue Date: 2014
ISSN: 1354-523X
Statement of
Y. Gu, Y. Zhang, C. Zhao, Y. Pan, R. J. Smales, H. Wang, Y. Ni, H. Zhang, J. Ni, J. Ma, L. Wang
Abstract: OBJECTIVES: The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with man- dibular prognathism (MP). METHODS: Sixty subjects in the early permanent denti- tion stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal control subjects in the early permanent dentition stage and 24 in the mixed dentition stage were recruited for comparison. According to the microarray-based expression profiling, four serum miRNAs (let-7i-3p, miR-595, miR-16-2-3p, and miR-367-5p) were validated. RESULTS: In the MP groups, let-7i-3p was significantly over-expressed in subjects in the early permanent (P < 0.0005) and mixed (P < 0.001) dentitions, and miR- 595 was significantly under-expressed (P < 0.004) in sub- jects in the early permanent (P < 0.004) and mixed (P < 0.0005) dentitions, compared with normal control groups. Multiple logistic regression analysis and receiver operating characteristic curve analysis revealed that let- 7i-3p and miR-595 were able to significantly discrimi- nate MP subjects from normal controls. CONCLUSION: Let-7i-3p and miR-595 could be poten- tial, non-invasive biomarkers for the accurate early detection and diagnosis of MP, which may result in improved clinical management.
Keywords: mandibular prognathism; microRNA; serum; marker
Rights: © 2013 John Wiley & Sons
RMID: 0020134377
DOI: 10.1111/odi.12073
Appears in Collections:Dentistry publications

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