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https://hdl.handle.net/2440/9085
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Type: | Journal article |
Title: | Elevated nerve growth factor levels in synovial fluid of patients with inflammatory joint disease |
Author: | Halliday, D. Zettler, C. Rush, R. Scicchitano, R. McNeil, J. |
Citation: | Neurochemical Research, 1998; 23(6):919-922 |
Publisher: | Springer Verlag |
Issue Date: | 1998 |
ISSN: | 0364-3190 1573-6903 |
Statement of Responsibility: | Dale A. Halliday, Christian Zettler, Robert A. Rush, Raffaele Scicchitano and Julian D. McNeil |
Abstract: | A novel pH shock extraction procedure was used to measure nerve growth factor (NGF) levels in both normal and inflamed synovial fluids using a sensitive and specific two-site enzyme linked immunosorbant assay. To date no data is available on NGF levels in normal synovial fluids. Synovial fluids were taken from 5 normal volunteers, 12 patients with rheumatoid arthritis and 10 patients with other inflammatory arthropathies. The mean ± SEM NGF concentration in normal synovial fluids was 95 ± 33.2 pg/ml (range 39.1–143.1 pg/ml), whereas the mean NGF concentration in the synovial fluids taken from patients with rheumatoid arthritis was 532.5 ± 123.8 pg/ml (range 152–1686 pg/ml). The mean NGF concentration in patients with other inflammatory arthropathies was also raised (430.6 ± 90 pg/ml; range 89–1071 pg/ml). The NGF concentrations were significantly higher in the synovial fluids from both inflamed groups (ANOVA p < 0.05)="" compared="" to="" normals.="" raised="" levels="" of="" ngf="" in="" synovial="" fluid="" may="" contribute="" directly="" to="" joint="" inflammation="" via="" activation="" of="" inflammatory="" |
Keywords: | Nerve growth factor; inflammation; arthritis; synovial fluid; pain |
Rights: | © 1998 Plenum Publishing Corporation |
DOI: | 10.1023/A:1022475432077 |
Published version: | http://dx.doi.org/10.1023/a:1022475432077 |
Appears in Collections: | Aurora harvest Medicine publications |
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