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Type: Journal article
Title: The ClC-KbT481S chloride channel gene polymorphism, ischaemic stroke and hypertension
Author: Milton, A.
Hamilton-Bruce, M.A.
Koblar, S.A.
Jannes, J.
Citation: The open neuroscience journal, 2008; 2(1):6-8
Publisher: Bentham Science Publishers
Issue Date: 2008
ISSN: 1874-0820
Statement of
J. Jannes, M.A. Hamilton-Bruce, A. Milton, S.A. Koblar
Abstract: Stroke is a polygenic disorder. Previous genetic studies focused on candidate genes influencing pathogenic processes, with little emphasis on genes influencing vascular risk factors. Previous research linked the ClC-KbT481S poly- morphism to blood pressure (BP). We therefore undertook an association study to determine the relevance of this poly- morphism to stroke, particularly lacunar stroke, given its strong correlation with hypertension. We genotyped DNA from 180 patients with acute ischaemic stroke (44 having lacunar stroke) and 298 age- and gender-matched controls using a se- quence-specific polymerase chain reaction method (SS-PCR). We found no association between the ClC-KbT481S poly- morphism and ischaemic stroke (Odds Ratio (OR): 0.87, 95% Confidence Interval (CI): 0.57-1.33). Stratification for stroke subtype did not alter this finding. This polymorphism showed a borderline association with history of hypertension (p=0.06) but was not associated with systolic or diastolic BP (p>0.05). To our knowledge there are no other studies pub- lished on this polymorphism and stroke.
Rights: © Milton et al.; Licensee Bentham Open. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.2174/1874082000802010006
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