Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/90885
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Type: Journal article
Title: The ClC-KbT481S chloride channel gene polymorphism, ischaemic stroke and hypertension
Author: Milton, A.
Hamilton-Bruce, M.A.
Koblar, S.A.
Jannes, J.
Citation: The open neuroscience journal, 2008; 2(1):6-8
Publisher: Bentham Science Publishers
Issue Date: 2008
ISSN: 1874-0820
Statement of
Responsibility: 
J. Jannes, M.A. Hamilton-Bruce, A. Milton, S.A. Koblar
Abstract: Stroke is a polygenic disorder. Previous genetic studies focused on candidate genes influencing pathogenic processes, with little emphasis on genes influencing vascular risk factors. Previous research linked the ClC-KbT481S poly- morphism to blood pressure (BP). We therefore undertook an association study to determine the relevance of this poly- morphism to stroke, particularly lacunar stroke, given its strong correlation with hypertension. We genotyped DNA from 180 patients with acute ischaemic stroke (44 having lacunar stroke) and 298 age- and gender-matched controls using a se- quence-specific polymerase chain reaction method (SS-PCR). We found no association between the ClC-KbT481S poly- morphism and ischaemic stroke (Odds Ratio (OR): 0.87, 95% Confidence Interval (CI): 0.57-1.33). Stratification for stroke subtype did not alter this finding. This polymorphism showed a borderline association with history of hypertension (p=0.06) but was not associated with systolic or diastolic BP (p>0.05). To our knowledge there are no other studies pub- lished on this polymorphism and stroke.
Rights: © Milton et al.; Licensee Bentham Open. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.2174/1874082000802010006
Published version: http://benthamopen.com/TONEURJ/VOLUME/2/
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