Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/90885
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DC Field | Value | Language |
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dc.contributor.author | Milton, A. | - |
dc.contributor.author | Hamilton-Bruce, M.A. | - |
dc.contributor.author | Koblar, S.A. | - |
dc.contributor.author | Jannes, J. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | The open neuroscience journal, 2008; 2(1):6-8 | - |
dc.identifier.issn | 1874-0820 | - |
dc.identifier.uri | http://hdl.handle.net/2440/90885 | - |
dc.description.abstract | Stroke is a polygenic disorder. Previous genetic studies focused on candidate genes influencing pathogenic processes, with little emphasis on genes influencing vascular risk factors. Previous research linked the ClC-KbT481S poly- morphism to blood pressure (BP). We therefore undertook an association study to determine the relevance of this poly- morphism to stroke, particularly lacunar stroke, given its strong correlation with hypertension. We genotyped DNA from 180 patients with acute ischaemic stroke (44 having lacunar stroke) and 298 age- and gender-matched controls using a se- quence-specific polymerase chain reaction method (SS-PCR). We found no association between the ClC-KbT481S poly- morphism and ischaemic stroke (Odds Ratio (OR): 0.87, 95% Confidence Interval (CI): 0.57-1.33). Stratification for stroke subtype did not alter this finding. This polymorphism showed a borderline association with history of hypertension (p=0.06) but was not associated with systolic or diastolic BP (p>0.05). To our knowledge there are no other studies pub- lished on this polymorphism and stroke. | - |
dc.description.statementofresponsibility | J. Jannes, M.A. Hamilton-Bruce, A. Milton, S.A. Koblar | - |
dc.language.iso | en | - |
dc.publisher | Bentham Science Publishers | - |
dc.rights | © Milton et al.; Licensee Bentham Open. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.source.uri | http://benthamopen.com/TONEURJ/VOLUME/2/ | - |
dc.title | The ClC-KbT481S chloride channel gene polymorphism, ischaemic stroke and hypertension | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2174/1874082000802010006 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hamilton-Bruce, M.A. [0000-0002-5222-620X] | - |
dc.identifier.orcid | Koblar, S.A. [0000-0002-8667-203X] | - |
dc.identifier.orcid | Jannes, J. [0000-0003-1440-2572] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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hdl_90885.pdf | Published version | 146.98 kB | Adobe PDF | View/Open |
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