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https://hdl.handle.net/2440/90901
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Type: | Journal article |
Title: | Statin use and pain in older people with cancer: a cross-sectional study |
Author: | Turner, J. Shakib, S. Singhal, N. Hogan-Doran, J. Prowse, R. Johns, S. Thynne, T. Bell, J. |
Citation: | Journal of the American Geriatrics Society, 2014; 62(10):1900-1905 |
Publisher: | Wiley |
Issue Date: | 2014 |
ISSN: | 0002-8614 1532-5415 |
Statement of Responsibility: | Justin P. Turner, Sepehr Shakib, Nimit Singhal, Jonathon Hogan-Doran, Robert Prowse, Sally Johns, Tilenka Thynne and J. Simon Bel |
Abstract: | OBJECTIVES: To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. DESIGN: Cross-sectional. SETTING: Medical oncology outpatient clinic at the Royal Adelaide Hospital. PARTICIPANTS: Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), of whom 106 were aged 80 and older. MEASUREMENTS: Participants completed a structured data collection instrument, documenting medication use, comorbidities and a general pain assessment (10-point visual analogue scale (VAS)). Unadjusted and adjusted logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with statin use. RESULTS: The prevalence of statin use was 35% (n = 97) in people aged 70 to 79 and 39% (n = 41) in those aged 80 and older. After adjusting for age, sex, Charlson Comorbidity Index, and analgesic use, statin use was associated with self-reported pain (VAS ≥ 5) (OR = 4.09, 95% CI = 1.32-12.68) in people aged 80 and older but not in those aged 70 to 79. Half of participants using statins (51% n = 70) had a palliative treatment approach. Of the 41 statin users aged 80 and older, 20 (49%) were using statins for primary prevention. CONCLUSION: The prevalence of statin use was similar in people aged 70 to 79 years and those aged 80 and older, with statin use associated with self-reported pain in people aged 80 and older. This highlights a potential benefit of "deprescribing" statins in older people with cancer, especially those aged 80 and older. |
Keywords: | aged; aged 80 and older; geriatric oncology; statins; HMG-CoA; deprescribe |
Rights: | © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society |
DOI: | 10.1111/jgs.13051 |
Published version: | http://dx.doi.org/10.1111/jgs.13051 |
Appears in Collections: | Aurora harvest 7 Medical Sciences publications |
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