Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/90943
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Type: Journal article
Title: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
Author: Lalla, R.
Bowen, J.
Barasch, A.
Elting, L.
Epstein, J.
Keefe, D.
McGuire, D.
Migliorati, C.
Nicolatou-Galitis, O.
Peterson, D.
Raber-Durlacher, J.
Sonis, S.
Elad, S.
The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO)
Citation: Cancer, 2014; 120(10):1453-1461
Publisher: Wiley
Issue Date: 2014
ISSN: 0008-543X
1097-0142
Statement of
Responsibility: 
Rajesh V. Lalla, Joanne Bowen, Andrei Barasch, Linda Elting, Joel Epstein, Dorothy M. Keefe, Deborah B. McGuire, Cesar Migliorati, Ourania Nicolatou-Galitis, Douglas E. Peterson, Judith E. Raber-Durlacher, Stephen T. Sonis, Sharon Elad and The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO)
Abstract: BACKGROUND: Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for mucositis. METHODS: A literature search was conducted to identify eligible published articles, based on predefined inclusion/exclusion criteria. Each article was independently reviewed by 2 reviewers. Studies were rated according to the presence of major and minor flaws as per previously published criteria. The body of evidence for each intervention, in each treatment setting, was assigned a level of evidence, based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation, suggestion, or no guideline possible. RESULTS: The literature search identified 8279 papers, 1032 of which were retrieved for detailed evaluation based on titles and abstracts. Of these, 570 qualified for final inclusion in the systematic reviews. Sixteen new guidelines were developed for or against the use of various interventions in specific treatment settings. In total, the MASCC/ISOO Mucositis Guidelines now include 32 guidelines: 22 for oral mucositis and 10 for gastrointestinal mucositis. This article describes these updated guidelines. CONCLUSIONS: The updated MASCC/ISOO Clinical Practice Guidelines for mucositis will help clinicians provide evidence-based management of mucositis secondary to cancer therapy.
Keywords: mucositis; stomatitis; oral; gastrointestinal; guidelines; Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO)
Rights: © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
RMID: 0030010732
DOI: 10.1002/cncr.28592
Appears in Collections:Medical Sciences publications

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