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Type: Journal article
Title: Breast cancer stem cells and the immune system: promotion, evasion and therapy
Author: Boyle, S.
Kochetkova, M.
Citation: Journal of Mammary Gland Biology and Neoplasia, 2014; 19(2):203-211
Publisher: Springer US
Issue Date: 2014
ISSN: 1083-3021
Statement of
Sarah T. Boyle, Marina Kochetkova
Abstract: Cancer stem cells are believed to be a subset of heterogeneous tumour cells responsible for tumour initiation, growth, local invasion, and metastasis. In breast cancer, numerous factors have been implicated in regulation of cancer stem cells, but there is still a paucity of information regarding precise molecular and cellular mechanisms guiding their pathobiology. Components of both the adaptive and the innate immune system have been shown to play a crucial role in supporting breast cancer growth and spread, and recently some immune mediators, both molecules and cells, have been reported to influence breast cancer stem cell biology. This review summarises a small, pioneering body of evidence for the potentially important function of the "immuniche" in maintaining and supporting breast cancer stem cells.
Keywords: Breast cancer; Cancer stem cells; Immune system; Chemokine; Cytokine; Immunotherapy
Rights: © Springer Science+Business Media New York 2014
DOI: 10.1007/s10911-014-9323-y
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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