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Type: Book chapter
Title: Approaches to evaluate gene-environment interactions underlying the developmental origins of health and disease
Author: Pennell Dr, C.E.
Palmer, L.J.
Knight, B.S.
Relton, C.
Lye, S.J.
Citation: Early life origins of human health and disease, 2009 / Newnham, J.P., Ross, M.G. (ed./s), pp.205-217
Publisher: S. Karger AG
Issue Date: 2009
ISBN: 9783805591393
Statement of
Craig E. Pennell, Lyle J. Palmer, Brian S. Knight, Caroline Relton, Stephen J. Lye
Abstract: Research studies have established a clear relationship between antenatal and postnatal environments and the development of adult diseases including the metabolic syndrome (coronary heart disease, stroke, insulin resistance, type 2 diabetes and dyslipidemia), obesity, neurologic disorders and mental illness [1]. These observations have been confirmed in multiple human populations and in numerous animal studies in multiple species. It is clear that the environment of mother, baby and child is a key contributor to diseases and conditions that account for approximately one third of the global burden of disease in both developed and developing countries. Although adverse antenatal and postnatal environments increase the risk of particular adult diseases, not all individuals exposed to these environments develop these conditions, suggesting that an individual’s genotype may contribute to the eventual outcome. Therefore, it has been suggested that gene-environment interactions underlie the developmental origins of health and disease (DOHaD).
Rights: © Copyright 2009 by S. Karger AG
RMID: 0030016367
DOI: 10.1159/000221166
Appears in Collections:Translational Health Science publications

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