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https://hdl.handle.net/2440/9125
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dc.contributor.author | Penttila, I. | - |
dc.contributor.author | van Spriel, A. | - |
dc.contributor.author | Zhang, M. | - |
dc.contributor.author | Xian, C. | - |
dc.contributor.author | Steeb, C.B. | - |
dc.contributor.author | Cummins, A. | - |
dc.contributor.author | Zola, H. | - |
dc.contributor.author | Read, L. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Pediatric Research, 1998; 44(4):524-531 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.issn | 1530-0447 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9125 | - |
dc.description.abstract | After birth, the gastrointestinal tract of the neonate is exposed to food and bacterial and environmental antigens. Maternal milk components may play a role in regulation of mucosal immune activity to luminal antigens. In this study we determine the ontogeny of transforming growth factor (TGF)-beta1-producing cells in the rat pup small intestine and assess maternal milk concentrations of TGF-beta. Intestinal tissue samples of duodenum and ileum were collected, processed, and stained for TGF-beta1, and in situ hybridization for TGF-beta1 mRNA was also performed on the duodenum. TGF-beta levels in milk were assayed by ELISA. TGF-beta2 levels in milk were high at d 6, and declined thereafter at d 10 and 19. TGF-beta1 was not detected. In contrast, the cell number and intensity of staining of TGF-beta1 peptide in the small intestine was low in 3- and 10-d-old rats and increased markedly by 19 d of life. In the duodenum mRNA levels mirrored this trend. TGF-beta1 expression in the lamina propria was absent before d 19, and increased progressively over time. Maternal milk TGF-beta2 levels are high in early milk and decrease during the weaning period. In contrast, endogenous TGF-beta production in the small intestine increases during the weaning period. | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.1203/00006450-199810000-00010 | - |
dc.subject | Intestinal Mucosa | - |
dc.subject | Duodenum | - |
dc.subject | Ileum | - |
dc.subject | Milk | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Wistar | - |
dc.subject | Transforming Growth Factor beta | - |
dc.subject | RNA, Messenger | - |
dc.subject | Immunohistochemistry | - |
dc.subject | In Situ Hybridization | - |
dc.subject | Transcription, Genetic | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Aging | - |
dc.subject | Postpartum Period | - |
dc.subject | Female | - |
dc.title | Transforming growth factor-β levels in maternal milk and expression in postnatal rat duodenum and ileum | - |
dc.title.alternative | Transforming growth factor-beta levels in maternal milk and expression in postnatal rat duodenum and ileum | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1203/00006450-199810000-00010 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Xian, C. [0000-0002-8467-2845] | - |
dc.identifier.orcid | Cummins, A. [0000-0003-3115-9498] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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