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Type: Journal article
Title: Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer
Author: Sun, X.
Ingman, W.
Citation: Journal of Mammary Gland Biology and Neoplasia, 2014; 19(2):191-201
Publisher: Springer US
Issue Date: 2014
ISSN: 1083-3021
Statement of
Xuan Sun and Wendy V. Ingman
Abstract: Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and their function is highly dependent on signals within the local cytokine microenvironment. The mammary epithelium secretes a number of cytokines, including colony stimulating factor 1 (CSF1), transforming growth factor beta 1 (TGFB1), and chemokine ligand 2 (CCL2) that affect the abundance, phenotype and function of macrophages. However, aberrations in these interactions have been found to increase the risk of tumour formation, and utilisation of stromal macrophage support by tumours can increase the invasive and metastatic potential of the cancer. Studies utilising genetically modified mouse models have shed light on the significance of epithelial cell-macrophage crosstalk, and the cytokines that mediate this communication, in mammary gland development and tumourigenesis. This article reviews the current status of our understanding of the roles of epithelial cell-derived cytokines in mammary gland development and cancer, with a focus on the crosstalk between epithelial cells and the local macrophage population.
Keywords: Macrophage; Cytokines; TGFB; CSF1; CCL2
Rights: © Springer Science+Business Media New York 2014
RMID: 0030014722
DOI: 10.1007/s10911-014-9319-7
Appears in Collections:Medicine publications

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