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Type: Journal article
Title: Impact of maternal obesity on offspring adipose tissue: lessons for the clinic
Author: Muhlhausler, B.
Vithayathil, M.
Citation: Expert Review of Endocrinology and Metabolism, 2014; 9(6):615-627
Publisher: Expert Reviews
Issue Date: 2014
ISSN: 1744-6651
Statement of
Beverly S. Muhlhausler, and Mini A. Vithayathil
Abstract: Maternal obesity is a major risk factor for the subsequent development of obesity and Type, diabetes in the child. This relationship appears to be driven largely by the exposure of the fetus to an increased nutrient supply during critical periods of development, which results in persistent changes in the structure and function of key systems involved in the regulation of energy balance, appetite and fat deposition. One of the key targets is the fat cell, or adipocyte, in which prenatal overnutrition programs a heightened capacity for fat storage. The increasing prevalence of maternal obesity has led to an urgent need for strategies to break the resulting intergenerational cycle of obesity and metabolic disease. This review will discuss the relationship between maternal obesity and poor metabolic health of the offspring, with a particular focus on the involvement of adipose tissue, recent clinical studies examining potential strategies for intervention and priority areas for further research.
Keywords: Obesity; pregnancy; maternal nutrition; adipose tissue; fetal programming; lipogenesis
Rights: Copyright © 2014 Informa Plc. All rights reserved.
DOI: 10.1586/17446651.2014.956088
Appears in Collections:Agriculture, Food and Wine publications
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