Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/91368
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Type: | Journal article |
Title: | Impact of maternal obesity on offspring adipose tissue: lessons for the clinic |
Author: | Muhlhausler, B. Vithayathil, M. |
Citation: | Expert Review of Endocrinology and Metabolism, 2014; 9(6):615-627 |
Publisher: | Expert Reviews |
Issue Date: | 2014 |
ISSN: | 1744-6651 1744-8417 |
Statement of Responsibility: | Beverly S. Muhlhausler, and Mini A. Vithayathil |
Abstract: | Maternal obesity is a major risk factor for the subsequent development of obesity and Type, diabetes in the child. This relationship appears to be driven largely by the exposure of the fetus to an increased nutrient supply during critical periods of development, which results in persistent changes in the structure and function of key systems involved in the regulation of energy balance, appetite and fat deposition. One of the key targets is the fat cell, or adipocyte, in which prenatal overnutrition programs a heightened capacity for fat storage. The increasing prevalence of maternal obesity has led to an urgent need for strategies to break the resulting intergenerational cycle of obesity and metabolic disease. This review will discuss the relationship between maternal obesity and poor metabolic health of the offspring, with a particular focus on the involvement of adipose tissue, recent clinical studies examining potential strategies for intervention and priority areas for further research. |
Keywords: | Obesity; pregnancy; maternal nutrition; adipose tissue; fetal programming; lipogenesis |
Rights: | Copyright © 2014 Informa Plc. All rights reserved. |
DOI: | 10.1586/17446651.2014.956088 |
Published version: | http://dx.doi.org/10.1586/17446651.2014.956088 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 2 |
Files in This Item:
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hdl_91368.pdf | Submitted version | 709.1 kB | Adobe PDF | View/Open |
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