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Type: Journal article
Title: Ruthenium complexes as antimicrobial agents
Author: Li, F.
Collins, J.
Keene, F.
Citation: Chemical Society Reviews, 2015; 44(8):2529-2542
Publisher: Royal Society of Chemistry
Issue Date: 2015
ISSN: 0306-0012
Statement of
Fangfei Li, J. Grant Collins and F. Richard Keene
Abstract: One of the major advances in medical science has been the development of antimicrobials; however, a consequence of their widespread use has been the emergence of drug-resistant populations of microorganisms. There is clearly a need for the development of new antimicrobials - but more importantly, there is the need for the development of new classes of antimicrobials, rather than drugs based upon analogues of known scaffolds. Due to the success of the platinum anticancer agents, there has been considerable interest in the development of therapeutic agents based upon other transition metals - and in particular ruthenium(ii/iii) complexes, due to their well known interaction with DNA. There have been many studies of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukaryotic cells over the last decade. However, only very recently has there been significant interest in their antimicrobial properties. This review highlights the types of ruthenium complexes that have exhibited significant antimicrobial activity and discusses the relationship between chemical structure and biological processing - including site(s) of intracellular accumulation - of the ruthenium complexes in both bacterial and eukaryotic cells.
Keywords: Animals
Anti-Infective Agents
Rights: ©2015 The Royal Society of Chemistry
DOI: 10.1039/c4cs00343h
Appears in Collections:Aurora harvest 7
Chemistry publications

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