Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Chemical Society Reviews, 2015; 44(8):2529-2542||-|
|dc.description.abstract||One of the major advances in medical science has been the development of antimicrobials; however, a consequence of their widespread use has been the emergence of drug-resistant populations of microorganisms. There is clearly a need for the development of new antimicrobials - but more importantly, there is the need for the development of new classes of antimicrobials, rather than drugs based upon analogues of known scaffolds. Due to the success of the platinum anticancer agents, there has been considerable interest in the development of therapeutic agents based upon other transition metals - and in particular ruthenium(ii/iii) complexes, due to their well known interaction with DNA. There have been many studies of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukaryotic cells over the last decade. However, only very recently has there been significant interest in their antimicrobial properties. This review highlights the types of ruthenium complexes that have exhibited significant antimicrobial activity and discusses the relationship between chemical structure and biological processing - including site(s) of intracellular accumulation - of the ruthenium complexes in both bacterial and eukaryotic cells.||-|
|dc.description.statementofresponsibility||Fangfei Li, J. Grant Collins and F. Richard Keene||-|
|dc.publisher||Royal Society of Chemistry||-|
|dc.rights||©2015 The Royal Society of Chemistry||-|
|dc.title||Ruthenium complexes as antimicrobial agents||-|
|dc.identifier.orcid||Keene, F. [0000-0001-7759-0465]||-|
|Appears in Collections:||Aurora harvest 7|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.