Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/91920
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Type: Journal article
Title: Shift work, long working hours and preterm birth: a systematic review and meta-analysis
Author: van Melick, M.
van Beukering, M.
Mol, B.
Frings-Dresen, M.
Hulshof, C.
Citation: International Archives of Occupational and Environmental Health, 2014; 87(8):835-849
Publisher: Springer-Verlag
Issue Date: 2014
ISSN: 0340-0131
1432-1246
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Responsibility: 
M. J. G. J. van Melick, M. D. M. van Beukering, B. W. Mol, M. H. W. Frings-Dresen, C. T. J. Hulshof
Abstract: PURPOSE: Specific physical activities or working conditions are suspected for increasing the risk of preterm birth (PTB). The aim of this meta-analysis is to review and summarize the pre-existing evidence on the effect of shift work or long working hours on the risk of PTB. METHODS: We conducted a systematic search in MEDLINE and EMBASE (1990-2013) for observational and intervention studies with original data. We only included articles that met our specific criteria for language, exposure, outcome, data collection and original data that were of at least of moderate quality. The data of the included studies were pooled. RESULTS: Eight high-quality studies and eight moderate-quality studies were included in the meta-analysis. In these studies, no clear or statistically significant relationship between shift work and PTB was found. The summary estimate OR for performing shift work during pregnancy and the risk of PTB were 1.04 (95% CI 0.90-1.20). For long working hours during pregnancy, the summary estimate OR was 1.25 (95% CI 1.01-1.54), indicating a marginally statistically significant relationship but an only slightly elevated risk. CONCLUSION: Although in many of the included studies a positive association between long working hours and PTB was seen this did reach only marginal statistical significance. In the studies included in this review, working in shifts or in night shifts during pregnancy was not significantly associated with an increased risk for PTB. For both risk factors, due to the lack of high-quality studies focusing on the risks per trimester, in particular the third trimester, a firm conclusion about an association cannot be stated.
Keywords: Preterm birth; Shift work; Working hours; Meta-analysis
Rights: © Springer-Verlag Berlin Heidelberg 2014
DOI: 10.1007/s00420-014-0934-9
Appears in Collections:Aurora harvest 7
Obstetrics and Gynaecology publications

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