Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/91951
Type: Journal article
Title: Psychological depression and cardiac surgery: a comprehensive review
Author: Tully, P.
Citation: Journal of Extra-Corporeal Technology, 2012; 44(4):224-232
Publisher: American Society of Extra-Corporeal Technology
Issue Date: 2012
ISSN: 0022-1058
Statement of
Responsibility: 
Phillip J. Tully
Abstract: The psychological and neurological impact of cardiac surgery has been of keen empirical interest for more than two decades although reports showing the prognostic influence of depression on adverse outcomes lag behind the evidence documented in heart failure, myocardial infarction, and unstable angina. The paucity of research to date is surprising considering that some pathophysiological mechanisms through which depression is hypothesized to affect coronary heart disease (e.g., platelet activation, the inflammatory system, dysrhythmias) are known to be substantially influenced by the use of cardiopulmonary bypass. As such, cardiac surgery may provide a suitable exemplar to better understand the psychiatric mechanisms of cardiopathogenesis. The extant literature is comprehensively reviewed with respect to the deleterious impact of depression on cardiac and neuropsychological morbidity and mortality. Research to date indicates that depression and major depressive episodes increase major cardiovascular morbidity risk after cardiac surgery. The association between depressive disorders and incident delirium is of particular relevance to cardiac surgery staff. Contemporary treatment intervention studies are also described along with suggestions for future cardiac surgery research.
Keywords: depression; depressive disorder; coronary artery bypass; coronary artery disease; antidepressive agents
Rights: Copyright status unknown
RMID: 0030014295
Appears in Collections:Surgery publications

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