Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9199
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Type: Journal article
Title: Effect of age on calcium absorption in postmenopausal women
Author: Nordin, B.
Need, A.
Morris, H.
O'Loughlin, P.
Horowitz, M.
Citation: American Journal of Clinical Nutrition, 2004; 80(4):998-1002
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2004
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
BE Christopher Nordin, Allan G Need, Howard A Morris, Peter D O’Loughlin, and Michael Horowitz
Abstract: It is assumed that calcium absorption decreases with age, but this is not well documented. We report a study that addresses this issue.The aim was to establish the extent and timing of any age-related change in calcium absorption in postmenopausal women.We measured radiocalcium absorption (alpha) in 262 healthy postmenopausal women aged 40-87 y. We also measured the serum vitamin D metabolites, parathyroid hormone (PTH), and other biochemical variables.Radiocalcium absorption decreased with age (P = 0.018); it was 28% lower in the 25 women aged >75 y than in the rest (P < 0.001). It was significantly related to serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D] in the whole set and in both the younger and older subsets, but it was not related to either 25-dihydroxyvitamin D [25(OH)D] or PTH or to any other measured variable. No decrease in 1,25(OH)(2)D was seen with age to account for the decrease in calcium absorption, so radiocalcium absorption corrected for serum 1,25(OH)(2)D decreased significantly after age 75 y. On multivariate analysis, the serum 1,25(OH)(2)D concentration was a positive function of 25(OH)D (P < 0.001), albumin (P = 0.010), and PTH (P = 0.012) and a negative function of serum creatinine (P = 0.003). PTH was a negative function of calculated ionized calcium (P = 0.004) and 25(OH)D (P = 0.009) and a positive function of weight (P = 0.011) and age (P = 0.028).A late age-related decrease in calcium absorption is seen in postmenopausal women in addition to the decline that occurs at menopause. This decrease could be due to a decline in either the active calcium transport or diffusion component of the calcium absorption system.
Keywords: calcium absorption; age; 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; parathyroid hormone
Description: © 2004 American Society for Clinical Nutrition
RMID: 0020041267
DOI: 10.1093/ajcn/80.4.998
Published version: http://www.ajcn.org/cgi/content/abstract/80/4/998
Appears in Collections:Medicine publications

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