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dc.contributor.authorSu, Y.-
dc.contributor.authorDoran, S.-
dc.contributor.authorWittert, G.-
dc.contributor.authorChapman, I.-
dc.contributor.authorJones, K.-
dc.contributor.authorSmout, A.-
dc.contributor.authorHorowitz, M.-
dc.identifier.citationAmerican Journal of Gastroenterology, 2002; 97(1):49-57-
dc.descriptionCopyright © 2002 by American College of Gastroenterology-
dc.description.abstract<h4>Objectives</h4>Corticotropin-releasing factor (CRF) has been shown to affect GI motor function and appetite in animals. We have evaluated the effects of exogenous CRF on antropyloroduodenal motility and appetite in humans.<h4>Methods</h4>On 2 separate days, six healthy volunteers received, in randomized, double-blind fashion, i.v. CRF as a 1.0-microg/kg bolus (0-5 min) followed by a constant infusion (1.0 microg/kg/h) (5-150 min), or an identical volume of saline. At t = 28 min each subject drank 200 ml of a nutrient liquid containing 20 mg/kg of paracetamol. Antropyloroduodenal pressures were measured with sleeve/sidehole manometry and perceptions of appetite by visual analog scales. Venous blood was obtained for measurements of serum cortisol and paracetamol. At t = 150 min the manometric catheter was removed and subjects offered a buffet meal (150-180 min). The amount and macronutrient content of food consumed were quantified.<h4>Results</h4>CRF increased serum cortisol (p < 0.001), the number of isolated pyloric pressure waves (p < 0.05), duodenal pressure waves (p < 0.05), and the percentage of antegrade duodenal pressure waves (p < 0.05). CRF had no significant effect on the number of antral pressure waves, basal pyloric pressure, serum paracetamol concentrations, perceptions of appetite, or food intake.<h4>Conclusions</h4>Intravenous CRF stimulates phasic pyloric and duodenal pressure waves in humans.-
dc.description.statementofresponsibilityYu-Chung Su, Selena Doran, Gary Wittert, Ian M. Chapman, Karen L. Jones, André J. P. M. Smout, and Michael Horowitz-
dc.publisherElsevier Science Inc-
dc.subjectCorticotropin-Releasing Hormone-
dc.subjectInfusions, Intravenous-
dc.subjectAnalysis of Variance-
dc.subjectSensitivity and Specificity-
dc.subjectDouble-Blind Method-
dc.subjectGastrointestinal Motility-
dc.subjectReference Values-
dc.titleEffects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans-
dc.typeJournal article-
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]-
dc.identifier.orcidJones, K. [0000-0002-1155-5816]-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
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