Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/92384
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Mouse models of mastitis - how physiological are they?
Author: Ingman, W.
Glynn, D.
Hutchinson, M.
Citation: International Breastfeeding Journal, 2015; 10(1):12-1-12-5
Publisher: BioMed Central Ltd.
Issue Date: 2015
ISSN: 1746-4358
1746-4358
Statement of
Responsibility: 
Wendy V Ingman, Danielle J Glynn, and Mark R Hutchinson
Abstract: Lactation mastitis is a common, but poorly understood, inflammatory breast disease that is a significant health burden. A better understanding of the aetiology of mastitis is urgently required, and will assist in the development of improved prevention and treatment strategies in both human and animal species. Studies in mice have the potential to greatly assist in identifying new drug candidates for clinical trials, and in developing a better understanding of the disease. Mouse models of mastitis involve administration of a mastitis-inducing agent to the mammary gland usually during lactation to examine the host immune response, and progression through to resolution of the disease. There are important variations in the protocols of these mouse models that critically affect the conclusions that can be drawn from the research. Some protocols involve weaning of offspring at the time of mastitis induction, and there are variations in the mastitis-inducing agent and its carrier. Induction of mammary gland involution through weaning of offspring limits the capacity to study the disease in the context of a lactating mammary gland. Administration of live bacteria in an aqueous carrier can cause sepsis, restricting the physiological relevance of the model. Mouse model research should employ appropriately designed controls and closely monitor the health of the mice. In this commentary, we discuss the advantages and study design limitations of each mouse model, and highlight the potential for further development of physiologically relevant mouse models of mastitis.
Keywords: Mastitis; Mouse models; Inflammation; Infection; Involution; Mammary gland
Description: Commentary
Rights: © 2015 Ingman et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
RMID: 0030026284
DOI: 10.1186/s13006-015-0038-5
Grant ID: http://purl.org/au-research/grants/arc/DP110100297
Appears in Collections:Physiology publications

Files in This Item:
File Description SizeFormat 
hdl_92384.pdfPublished version2.57 MBAdobe PDFView/Open
hdl_92384_version.pdfVersion information137.07 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.